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Sibrotuzumab (CAT#: TAB-211)

Datasheet
DESCRIPTION CATALOG # SIZE PRICE
Anti-Human FAP Recombinant Antibody TAB-211 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant monoclonal antibody to FAP. Sibrotuzumab is a humanized monoclonal antibody intended for the treatment of cancer. It binds to FAP.
  • Target
  • FAP
  • Type
  • IgG1 - kappa
  • Immunogen
  • A synthetic peptide derived from human Fibroblast activation protein, alpha.
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in ELISA, IP, FC, FuncS, Neut, IF, WB and most other immunological methods.
  • CAS
  • 216669-97-5
  • Specific Activity
  • Tested positive against native human antigen.
  • Protein Construction
  • Immunoglobulin G1, anti-(human FAP (fibroblast activation protein)) (human-mouse monoclonal BIBH1 g1-chain), disulfide with human-mouse monoclonal BIBH1 k-chain, dimer
  • Purity
  • >95.0% as determined by analysis by SDS-PAGE.
  • Size
  • 1mg
  • Storage
  • Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.

BACKGROUND

  • Antigen Description
  • In association with DPP4 is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May have a role in tissue remodeling during development and wound healing, and may contribute to invasiveness in malignant cancers.
  • Function
  • dipeptidyl-peptidase activity; endopeptidase activity; metalloendopeptidase activity; peptidase activity; protease binding; protein binding; protein dimerization activity; protein homodimerization activity; serine-type endopeptidase activity; serine-type
  • Synonyms
  • FAP; fibroblast activation protein, alpha; seprase; DPPIV; integral membrane serine protease; 170 kDa melanoma membrane-bound gelatinase; FAPA; DKFZp686G13158;

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